Prescription
Prescription RequiredCompoundedBi-Est (80/20) Cream
Bi-Est Cream is a compounded hormonal therapy cream used for hormone replacement in women experiencing menopause symptoms. It contains a blend of two estrogens, estradiol and estriol, which help alleviate symptoms like hot flashes and vaginal dryness.
Requires a valid prescription from your provider. Not sure if it's right for you? Ask a pharmacist.
These statements have not been evaluated by the Food and Drug Administration. Compounded products are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. This information is for educational purposes only and is not medical advice — always consult your healthcare provider before starting any new treatment.
Clinical information
Medication information for patients and providers.
Apply one pump of cream to clean, dry skin once daily, rotating application sites between the inner thighs or arms. If you miss a dose, apply as soon as you remember unless it's close to the next dose. Do not double doses.
Bi-Est Cream supplements two estrogens that decrease during menopause. Estradiol and estriol bind to estrogen receptors in the body, helping to restore hormonal balance. Patients may notice reduced hot flashes and improved vaginal moisture within weeks.
Do not use if you have a history of breast cancer, estrogen-dependent tumors, or blood clot disorders. Not for use during pregnancy or breastfeeding, as it can harm the baby. Avoid if allergic to any ingredients in the cream.
Estrogen creams may interact with thyroid medications, blood thinners like warfarin, and certain epilepsy treatments. Inform your doctor of all substances you ingest. Alcohol may increase side effects, so use in moderation.
Common side effects (may affect 1-10 people out of 100): skin irritation at the application site, headache, nausea. Rare but serious: blood clots, breast tenderness, or unusual vaginal bleeding. Contact your doctor if side effects become severe or troublesome.
Store at room temperature (68-77°F, 20-25°C) in its original container. Protect from excessive heat and light. Do not refrigerate or freeze. Keep out of reach of children and pets. Dispose of responsibly through pharmacy take-back programs.
Frequently asked questions.
Apply the cream to clean, dry skin on the inner thighs or arms, rotating sites to avoid irritation. Use one pump per day unless directed otherwise by your doctor.
If you miss a dose, apply it as soon as you remember unless it's almost time for your next application. Do not double up doses to make up for a missed one.
While using this cream, you can continue your regular diet, but try to limit excessive alcohol consumption as it may worsen side effects.
No, it's not safe to use Bi-Est Cream if you're pregnant or breastfeeding, as it may harm the baby. Consult your doctor for safer alternatives.
Many patients notice improvement in menopause symptoms like hot flashes and vaginal dryness within a few weeks of regular use.
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