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Available Strengths (4)·Most prescribed
Active Ingredients
Important Disclaimer
These statements have not been evaluated by the Food and Drug Administration (FDA). Compounded products are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. The information provided is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting any new treatment.
Clinical Information
Evidence-based details for healthcare providers
Apply one pump of cream to clean, dry skin once daily, rotating application sites between the inner thighs or arms. If you miss a dose, apply as soon as you remember unless it's close to the next dose. Do not double doses.
Bi-Est Cream supplements two estrogens that decrease during menopause. Estradiol and estriol bind to estrogen receptors in the body, helping to restore hormonal balance. Patients may notice reduced hot flashes and improved vaginal moisture within weeks.
Do not use if you have a history of breast cancer, estrogen-dependent tumors, or blood clot disorders. Not for use during pregnancy or breastfeeding, as it can harm the baby. Avoid if allergic to any ingredients in the cream.
Estrogen creams may interact with thyroid medications, blood thinners like warfarin, and certain epilepsy treatments. Inform your doctor of all substances you ingest. Alcohol may increase side effects, so use in moderation.
Common side effects (may affect 1-10 people out of 100): skin irritation at the application site, headache, nausea. Rare but serious: blood clots, breast tenderness, or unusual vaginal bleeding. Contact your doctor if side effects become severe or troublesome.
Store at room temperature (68-77°F, 20-25°C) in its original container. Protect from excessive heat and light. Do not refrigerate or freeze. Keep out of reach of children and pets. Dispose of responsibly through pharmacy take-back programs.
Frequently Asked Questions
How do I apply Bi-Est Cream?
Apply the cream to clean, dry skin on the inner thighs or arms, rotating sites to avoid irritation. Use one pump per day unless directed otherwise by your doctor.
What should I do if I miss a dose?
If you miss a dose, apply it as soon as you remember unless it's almost time for your next application. Do not double up doses to make up for a missed one.
Are there any foods or drinks I should avoid?
While using this cream, you can continue your regular diet, but try to limit excessive alcohol consumption as it may worsen side effects.
Can I use this cream while pregnant or breastfeeding?
No, it's not safe to use Bi-Est Cream if you're pregnant or breastfeeding, as it may harm the baby. Consult your doctor for safer alternatives.
When will I start seeing results from using Bi-Est Cream?
Many patients notice improvement in menopause symptoms like hot flashes and vaginal dryness within a few weeks of regular use.
Related Products
Bi-Est (80/20) Rapid Dissolving Tablet (RDT)
Biest Rapid Dissolving Tablet combines estradiol and estriol in an 80/20 ratio for hormone replacement therapy to manage symptoms of menopause such as hot flashes and vaginal dryness.
Bi-Est (50/50) Cream
This compounded cream contains equal parts estradiol and estriol, two forms of estrogen. It is applied to the skin to help relieve symptoms of low estrogen such as hot flashes, night sweats, and vaginal dryness. Because this is a compounded medication, it is prepared by a licensed pharmacy for your individual needs and is not reviewed by the FDA for safety or effectiveness.
Estradiol Cream
Estradiol Cream is a bio-identical hormone replacement therapy (BHRT) made for women who need extra estrogen. The cream uses an advanced base that helps the medicine pass through the skin evenly. It is most often prescribed to ease menopausal symptoms such as hot flashes, night sweats, and vaginal dryness.
Estradiol Rapid Dissolve Tablets
Estradiol Rapid Dissolve Tablets supply bio-identical estrogen to ease common menopause symptoms like hot flashes, night sweats, mood swings, and vaginal dryness. The quick-dissolve design melts on your tongue without water, making daily dosing simple and comfortable.