Prescription
Prescription RequiredCompoundedProgesterone MR Capsules
Progesterone MR (modified-release) Capsules provide a steady release of natural progesterone for hormone replacement therapy (HRT). They are commonly used to balance estrogen, support a healthy uterine lining, reduce hot flashes, and ease other symptoms of low progesterone. The modified-release design helps maintain stable blood levels through the night, which can improve sleep and lower next-day dizziness.
Requires a valid prescription from your provider. Not sure if it's right for you? Ask a pharmacist.
These statements have not been evaluated by the Food and Drug Administration. Compounded products are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. This information is for educational purposes only and is not medical advice — always consult your healthcare provider before starting any new treatment.
Clinical information
Medication information for patients and providers.
Use as directed by your healthcare provider. Swallow the capsule whole with a glass of water, usually at bedtime. If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not take two doses together. Your healthcare provider will decide how long you should keep taking this medicine.
Progesterone attaches to progesterone receptors found in the uterus, brain, and other tissues. It balances the effects of estrogen, thickens the uterine lining for possible pregnancy, and lowers the risk of uncontrolled tissue growth. After swallowing, the modified-release capsule starts releasing medicine in about 1 hour, with peak levels around 6–8 hours, and effects lasting up to 24 hours. Patients often notice better sleep and fewer hot flashes within 1–2 weeks, while full hormonal balance may take 1–3 months.
Do not use if you are pregnant unless your provider specifically prescribes it for pregnancy support. Do not use if you have breast cancer, estrogen- or progesterone-dependent tumors, unexplained vaginal bleeding, active or past blood clots, stroke, heart attack, or severe liver disease (including liver tumors). Do not use if you are allergic to progesterone, peanuts (some formulations contain peanut oil), or any capsule ingredients. Not for use in children. Use caution if you have asthma, migraines, epilepsy, kidney disease, or depression—talk to your provider first.
May reduce seizure control when taken with certain anticonvulsants (e.g., phenytoin, carbamazepine). May increase blood levels of some heart medicines such as verapamil or diltiazem, raising dizziness risk. Hormone therapies containing estrogen or testosterone can increase side effects. Use with blood thinners like warfarin may change bleeding risk—your INR may need closer checks. Herbal supplements like St. John’s wort can lower progesterone levels and make it less effective. Limit alcohol and caffeine, which may worsen dizziness or insomnia.
Very common (more than 1 in 10 people): drowsiness, mild dizziness, bloating. Common (1–10 in 100 people): headache, breast tenderness, mood swings, nausea, mild swelling of hands or feet. Uncommon (1–10 in 1,000 people): acne, hair changes, mild depression, spotting between periods. Rare but serious (less than 1 in 1,000 people): blood clots in legs or lungs (pain, swelling, shortness of breath), yellowing of skin or eyes (liver problems), severe allergic reaction (rash, swelling of face or throat). Most mild side effects improve within a few weeks; contact your provider if they persist or if you notice any serious symptoms.
Store at room temperature (68–77°F, 20–25°C) in a dry place away from direct light. Keep capsules in the original, tightly closed container. Do not store in the bathroom or near a sink. Protect from high humidity and heat. Keep out of reach of children and pets. Dispose of unused or expired capsules through a pharmacy take-back program or mix them with used coffee grounds in a sealed plastic bag before placing in household trash.
Frequently asked questions.
Most people take it at bedtime because it can cause sleepiness. Taking it the same time each night helps keep hormone levels steady and lowers daytime drowsiness.
Some improvements like better sleep or fewer night sweats may appear in 1–2 weeks. Full symptom relief usually takes 1–3 months of regular use.
No. The capsule is modified-release, so breaking it would release the medicine too fast and reduce its effect. Swallow it whole with water.
Small amounts are generally safe, but alcohol can increase dizziness and drowsiness. If you choose to drink, do so in moderation and see how your body reacts.
Light spotting can happen when starting therapy and often settles in a few cycles. If bleeding is heavy, lasts more than a few days, or worries you, call your healthcare provider.
Tell your surgeon and anesthesiologist you use progesterone. They may advise stopping it 4–6 weeks before major surgery to lower blood-clot risk. Always follow your provider’s instructions.
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