Prescription
Prescription RequiredCompoundedGreer's Goo
This compounded ointment, often called “Greer's Goo,” combines an antifungal (nystatin), a mild steroid (hydrocortisone 1%), and a skin-protecting barrier (zinc oxide 20%). It is designed for inflamed, irritated, or yeast-infected skin folds such as diaper areas. The mixture fights yeast, calms redness and itching, and shields the skin from moisture to help it heal.
Requires a valid prescription from your provider. Not sure if it's right for you? Ask a pharmacist.
These statements have not been evaluated by the Food and Drug Administration. Compounded products are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. This information is for educational purposes only and is not medical advice — always consult your healthcare provider before starting any new treatment.
Clinical information
Medication information for patients and providers.
Use as directed by your healthcare provider. Apply a thin layer to the affected skin after cleaning and drying the area. If you miss an application, use it when you remember unless it is almost time for the next one. Do not apply extra amounts or cover with tight dressings unless told to do so.
Nystatin attaches to a substance called ergosterol in the yeast cell wall, making holes that kill the fungus. Hydrocortisone is a mild steroid that lowers chemicals in the skin that cause swelling, redness, and itching; relief is often felt within a few hours. Zinc oxide forms a physical barrier that keeps moisture and irritants away from the skin while also having mild soothing properties. Most people notice less redness and discomfort within 2–3 days, but full healing can take up to 1–2 weeks of regular use.
Do not use if you are allergic to nystatin, hydrocortisone, zinc oxide, or any other ingredient in this ointment (may cause rash or swelling). Do not use on viral skin infections such as cold sores or chickenpox lesions, on untreated bacterial infections, or on open deep wounds. Avoid use in the eyes, inside the mouth, or inside the vagina. Talk to your healthcare provider before use if you are pregnant, breastfeeding, or if the patient is under 2 years old. Long-term or large-area use of topical steroids is not advised without medical supervision because it can thin the skin.
Because this product is used on the skin, drug interactions are uncommon. Still, tell your healthcare provider about all medicines, creams, and herbal products you use. Using other topical steroids or antifungals on the same area may raise the chance of side effects or irritation. If you are on immune-suppressing drugs (like oral steroids, methotrexate, or cyclosporine), discuss with your provider as combined effects may weaken your immune response. Avoid applying harsh cleansers, alcohol-based products, or abrasive scrubs on the treated area—they can worsen irritation.
Common (up to 1 in 10 users): mild burning, stinging, or itching for a few minutes after application, slight skin dryness. Uncommon (1 in 100 to 1 in 1,000): skin thinning, stretch marks, light or dark spots, acne-like bumps, increased hair growth at the site. Rare but serious: allergic contact dermatitis (red rash, swelling, blistering), secondary bacterial infection, or adrenal suppression with large-area or long-term steroid use. Most mild effects fade as skin heals; stop use and call your provider if severe redness, swelling, or worsening rash occurs.
Store tightly closed at room temperature 68-77°F (20-25°C). Do not freeze. Keep away from direct sunlight, excess heat, and high humidity such as bathrooms. Use clean hands or a disposable applicator to avoid contaminating the jar. Keep out of reach of children and pets. Discard any unused ointment 6 months after opening or by the beyond-use date given by the pharmacy. Return expired product to a pharmacy take-back program or seal in a plastic bag with household trash if no program is available.
Frequently asked questions.
Follow your provider’s directions. Most people apply it two to four times a day after each diaper change or as advised. Do not over-apply; a thin layer is enough.
Redness and discomfort often start to ease within 2–3 days. Full clearing can take up to a week or longer, depending on how severe the rash is. Keep using it as prescribed even if the skin looks better early.
This ointment is meant for inflamed but mostly intact skin. Do not apply to deep open wounds without your provider’s approval, as it may delay healing or let germs in.
Avoid layering multiple products unless your provider says it is okay. Extra creams or powders can dilute the medication or trap moisture, making the rash worse.
Stop using the ointment and contact your healthcare provider. The rash may be due to bacteria, allergies, or another cause that needs different treatment.
Zinc oxide can leave white residue on fabric. Let the ointment absorb for a minute and use protective liners in diapers or clothing to reduce staining.
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