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Important Disclaimer
These statements have not been evaluated by the Food and Drug Administration (FDA). Compounded products are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. The information provided is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting any new treatment.
Clinical Information
Evidence-based details for healthcare providers
Use as directed by your healthcare provider. Take with food to lower stomach upset. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Do not take two doses at the same time. Your healthcare provider will decide how long you should take this medication.
Trazodone balances a brain chemical called serotonin. It blocks certain serotonin receptors and slows the re-uptake of serotonin so more stays active between nerve cells. You may feel calmer or sleepier after the first dose, but mood benefits often take 1–2 weeks to appear and up to 4–6 weeks for full effect. The calming effect usually lasts about 6–8 hours after each dose.
Do not use if you are allergic to trazodone or any tablet ingredients (can cause rash, swelling, or breathing trouble). Do not use if you have taken an MAO inhibitor (such as phenelzine, tranylcypromine, selegiline, linezolid, or methylene blue) within the past 14 days; this can lead to dangerous serotonin levels. Avoid if you have recently had a heart attack or have certain heart rhythm problems without your doctor's approval, as trazodone can affect heart rhythm. Not for children under 18 unless specifically prescribed. Talk to your doctor before use if pregnant, planning pregnancy, or breastfeeding.
High-risk interactions: MAO inhibitors (Nardil, Parnate), other serotonin-raising drugs like SSRIs (Zoloft, Prozac), SNRIs (Effexor), triptans for migraines, and tramadol can increase the chance of serotonin syndrome—seek medical help if you get severe agitation, fever, or stiff muscles. Strong CYP3A4 inhibitors such as ketoconazole, clarithromycin, or grapefruit juice can raise trazodone levels and side effects. Digoxin or phenytoin levels may rise, leading to toxicity—monitor levels if used together. Alcohol and other sleep aids or antihistamines increase drowsiness and fall risk. Blood thinners like warfarin may increase bleeding risk. Always tell your healthcare provider about all prescriptions, over-the-counter medicines, vitamins, and herbal supplements (especially St. John’s wort and valerian). Limit alcohol to reduce dizziness.
Very common (affects more than 1 in 10 people): sleepiness, dizziness, dry mouth. Common (1–10 in 100 people): headache, blurred vision, nausea, vomiting, constipation, stuffy nose, low blood pressure when standing (feeling light-headed). Uncommon (1–10 in 1000): confusion, nightmares, tremor, weight change, sweating, ringing in ears. Rare but serious: prolonged or painful erection (priapism), fast or irregular heartbeat, serotonin syndrome (high fever, rigid muscles, confusion), allergic reaction (rash, swelling of face/lips). Most mild side effects ease after a few days to weeks. Seek medical care right away for chest pain, fainting, severe dizziness, or priapism lasting longer than 4 hours.
Store at room temperature (68–77°F, 20–25°C). Keep tablets in the original, tightly closed container. Protect from moisture and direct sunlight. Do not store in the bathroom or near the kitchen sink. Keep out of reach of children and pets. Dispose of unused or expired tablets through a pharmacy take-back program or mix with coffee grounds or cat litter in a sealed bag before throwing in household trash.
Frequently Asked Questions
How should I take trazodone to help me sleep?
Take it exactly as your healthcare provider instructs, usually once before bedtime with a small snack. Swallow the tablet whole or split only if your provider tells you the exact half-dose.
When will I start feeling better?
Many people feel calmer or sleepier after the first few doses, but mood improvements can take 1–2 weeks and sometimes up to 6 weeks. Keep taking it as prescribed even if you do not feel better right away.
Can I drink alcohol while on trazodone?
Limit or avoid alcohol. Both alcohol and trazodone cause drowsiness and low blood pressure, increasing your risk of severe dizziness, falls, or impaired thinking.
What should I do if I feel very dizzy when I stand up?
Stand up slowly, especially from sitting or lying positions. If dizziness does not improve or you faint, call your healthcare provider. They may adjust your dose or timing.
Is trazodone safe to use during pregnancy?
Talk to your doctor first. Limited data exist on trazodone in pregnancy. Your provider will weigh the benefits against possible risks and may suggest other options.
Can I cut the 50 mg tablet in half?
Yes, the tablet is scored, but only split it if your healthcare provider tells you to. Use a tablet cutter to ensure an even dose.
What happens if I stop taking trazodone suddenly?
Stopping without guidance may cause withdrawal symptoms like anxiety, irritability, or trouble sleeping. Always talk to your provider who will create a plan to lower your dose slowly if needed.
Does trazodone interact with herbal supplements?
Yes. St. John’s wort, valerian, and kava may increase sedation or raise serotonin levels. Always tell your provider about any supplements before starting trazodone.
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