Clinical Information
Use as directed by your healthcare provider. Inject the prescribed amount under the skin of your stomach, thigh, or upper arm. If you miss a dose, inject it as soon as you remember unless your next scheduled dose is less than 48 hours away. Do not give two doses at the same time. Your provider will decide how long you should stay on this medicine.
Tirzepatide attaches to two natural gut hormone receptors called GIP and GLP-1. By activating these receptors, it tells your pancreas to release insulin when blood sugar is high, slows stomach emptying so you feel full longer, and lowers the signal that tells your liver to make sugar. Most people begin to see lower blood sugar within the first week and gradual weight loss over 4-12 weeks. Vitamin B6 helps your body turn food into energy and keeps nerves working properly, which can be helpful during weight-loss programs. The combined effect supports better blood sugar control and may reduce appetite.
Do not use if you are allergic to tirzepatide, vitamin B6, or any ingredient in this product (may cause severe rash or swelling). Do not use if you or a family member has ever had medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) because tirzepatide may increase thyroid tumor risk. Avoid during pregnancy or while trying to become pregnant; weight loss drugs can harm a developing baby. Not recommended while breastfeeding. Do not use if you have severe stomach or intestinal disease that slows movement (such as gastroparesis) or if you have active pancreatitis.
Using this medicine with insulin or sulfonylureas (examples: glipizide, glyburide) can cause low blood sugar—check levels often and talk to your provider about dose changes. Tirzepatide may slow how fast your stomach empties; this can affect oral medicines such as birth control pills, pain relievers, or antibiotics—take those at least 1 hour before or 4 hours after injection if advised. Vitamin B6 can interfere with levodopa (Parkinson’s drug) and increase the breakdown of certain seizure medicines like phenytoin. Isoniazid (for tuberculosis) may reduce vitamin B6 levels and raise nerve-damage risk. Limit alcohol because it raises pancreatitis risk and can worsen low blood sugar.
Very common (more than 1 in 10 people): nausea (18-20%), diarrhea (12-15%), decreased appetite (10-12%). Common (1-10 in 100 people): vomiting, constipation, stomach pain, injection-site redness, fatigue, mild low blood sugar when used with other diabetes drugs. Uncommon (1-10 in 1000 people): gallbladder problems, pancreatitis, allergic reactions, dizziness. Rare but serious: severe low blood sugar, severe stomach pain that will not go away (possible pancreatitis), signs of thyroid tumor (lump in neck, hoarse voice, trouble swallowing). Most stomach side effects improve after the first 4-6 weeks. Call your provider if side effects are severe, last more than a few weeks, or you notice signs of allergic reaction or pancreatitis.
Store unopened vials in a refrigerator at 36-46°F (2-8°C). Keep in the original box to protect from light. Do not freeze—throw away if the solution has frozen. After first use, the vial may be kept refrigerated or at room temperature up to 77°F (25°C) for 28 days; keep the rubber stopper clean and do not expose to direct sunlight or high heat. Do not shake. Discard any unused solution 28 days after first puncture or on the beyond-use date on the label, whichever comes first. Dispose of needles and empty vials in an FDA-cleared sharps container or follow local regulations.
Frequently Asked Questions
Q:How do I inject this medicine?
A:Clean the skin with an alcohol swab, pinch a fold of skin on your belly, thigh, or upper arm, insert the needle at a 90-degree angle, and push the plunger slowly. Rotate sites with each dose to avoid irritation.
Q:When will I start losing weight?
A:Most people notice a smaller appetite within the first week and gradual weight loss over the next 1-3 months. Steady lifestyle changes like healthy eating and regular activity will help you reach your goals faster.
Q:What should I do if I feel very sick to my stomach?
A:Eat smaller meals, avoid greasy or spicy foods, and sip clear liquids. If nausea or vomiting is severe or lasts more than a few days, call your healthcare provider—they may adjust your dose or give anti-nausea medicine.
Q:Can I take this with my other diabetes pills?
A:Yes, but some diabetes medicines, especially sulfonylureas and insulin, can cause low blood sugar when combined. Monitor your levels closely and speak with your provider about lowering doses of those drugs if needed.
Q:Is it safe to drink alcohol while using tirzepatide?
A:Small, occasional amounts may be fine for many people, but alcohol can raise the chance of low blood sugar and pancreatitis. Limit or avoid alcohol and always check your blood sugar if you choose to drink.
Q:What happens if I miss a dose?
A:If it has been less than 4 days since the missed dose, inject it as soon as you remember and continue your regular schedule. If more than 4 days have passed, skip the missed dose and take your next one on the usual day. Never inject extra medicine to make up for a missed dose.
Q:Can pregnant or breastfeeding women use this medication?
A:No. Weight-loss drugs can harm a developing baby, and it is not known if tirzepatide passes into breast milk. Talk with your doctor about safer options if you are pregnant, planning pregnancy, or nursing.
Q:How should I store my injection supplies when traveling?
A:Carry vials in an insulated cooler pack with ice packs to keep them between 36-46°F (2-8°C). Do not place directly on ice. Keep vials in their box, and bring extra needles, alcohol swabs, and a sharps container or travel-safe disposal kit.
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