Clinical Information
Use as directed by your healthcare provider. Place one tablet under your tongue and allow it to dissolve completely without chewing or swallowing whole. If you miss a dose intended for planned sexual activity, take it when needed unless your provider tells you otherwise. Do not take more than one dose in 24 hours unless specifically instructed. Never double up on doses.
Tadalafil blocks the enzyme PDE5, which relaxes blood vessels in the penis and improves blood flow. This helps you get and keep an erection when sexually aroused. Apomorphine HCl is a dopamine agonist that acts on brain pathways involved in sexual response, helping start the erection process. The tablet usually begins to work within 15–30 minutes and may last up to 6 hours. Full benefit depends on sexual stimulation.
Do not use if you take nitrates such as nitroglycerin or isosorbide (can cause dangerous blood pressure drops). Do not use if you take riociguat for pulmonary hypertension. Do not use if you are allergic to tadalafil, apomorphine, or any ingredients in this medication. Avoid if you have severe heart disease, recent heart attack or stroke (within 6 months), uncontrolled low or high blood pressure, or severe liver or kidney disease. Not for use in women, children, or teens under 18.
Serious interactions can occur with nitrates (Nitrostat, Imdur), guanylate cyclase stimulators (Adempas), and alpha-blockers (tamsulosin) leading to low blood pressure. Strong CYP3A4 inhibitors like ketoconazole, clarithromycin, and ritonavir can raise tadalafil levels and side effects. Blood pressure medicines, alcohol, and other PDE5 inhibitors (sildenafil, vardenafil) may add to dizziness or fainting risk. Dopamine-acting drugs or antipsychotics may increase nausea with apomorphine. Tell your provider about all prescription drugs, OTC medicines, and herbal supplements such as nitrates in chest ointments or recreational “poppers.” Limit alcohol to no more than two drinks and avoid grapefruit juice while using this medication.
Very common (more than 1 in 10): headache, flushing, stuffy nose. Common (1–10 in 100): nausea, dizziness, indigestion, back pain, mild drop in blood pressure, slight vision changes (blue tint). Uncommon (1–10 in 1,000): fainting, prolonged erection over 4 hours (priapism), sudden hearing decrease, severe low blood pressure. Rare but serious: heart attack symptoms, stroke symptoms, severe allergic reaction (rash, swelling of face or throat). Most mild side effects last a few hours. Seek medical help right away for chest pain, vision or hearing loss, or an erection lasting longer than 4 hours.
Store at room temperature 68–77 °F (20–25 °C) in the original, tightly closed container. Keep tablets dry—do not remove desiccant packs. Protect from moisture, heat, and direct sunlight. Do not store in bathroom or refrigerator. Keep out of reach of children and pets. Discard any unused tablets 6 months after opening or by the expiration date, whichever comes first. Use a pharmacy take-back program or mix tablets with coffee grounds in a sealed bag before placing in household trash.
Frequently Asked Questions
Q:How fast will the tablet start working?
A:Most men feel effects in about 15 to 30 minutes after the tablet fully dissolves under the tongue. Take it only when you plan sexual activity and allow enough time for it to work.
Q:Can I swallow the tablet instead of letting it dissolve?
A:No. The tablet is meant to dissolve under your tongue for quicker absorption. Swallowing it whole may delay or lessen its effect.
Q:Is it safe to drink alcohol while using this medication?
A:One or two standard drinks are usually okay, but heavy drinking can lower blood pressure and increase dizziness. Limit alcohol and do not drink to excess before taking the tablet.
Q:What should I do if I get a headache or nausea?
A:Mild headache or nausea often passes within a few hours. Drink water, rest, or take an over-the-counter pain reliever your provider approves. If symptoms are severe or last more than a day, call your healthcare professional.
Q:Can I take this with my blood pressure medicine?
A:Some blood pressure drugs may add to the blood-pressure-lowering effect of this tablet. Never change or stop your blood pressure medicine on your own. Discuss all your medications with your prescriber so they can adjust doses or timing safely.
Q:What if I have an erection that lasts too long?
A:An erection lasting more than 4 hours is a medical emergency called priapism. Call 911 or go to the nearest emergency room immediately to prevent long-term damage.
Q:How should I store the tablets when traveling?
A:Keep them in their original container, tightly closed, and away from direct sun or heat sources like a car dashboard. Do not place them in checked luggage exposed to extreme temperatures.
Related Products
Quad-Mix
This compounded injectable medication (often called “Quad-Mix”) contains four active drugs that work together to improve erectile function in adult men. When injected into the side of the penis before sexual activity, the medicine relaxes smooth muscle, widens blood vessels, and reduces outflow so more blood stays in the erectile tissue. A very small volume is used, and the effect starts within about 5–20 minutes and can last 30–90 minutes. Because it is a sterile compound prepared for each patient, strength ratios and vial size may vary based on your prescriber’s order.
Climax Cream
This compounded cream combines four blood-flow–enhancing agents—Theophylline 3%, Arginine 6%, Ergoloid Mesylate 0.05%, and Pentoxifylline 5%—to increase circulation when applied to intimate skin. It is dispensed in a 30-gram metered pump for easy, accurate dosing. The formula is designed for adults who want faster, stronger genital arousal. Use only as directed by your prescriber.
Euphoria Cream
Euphoria Cream is a topical prescription blend used to boost female sexual arousal. The combination of arginine, papaverine, and alprostadil widens blood vessels in sensitive tissues, helping increase warmth, sensation, and natural lubrication. It is applied directly to external genital skin to support satisfying intimacy when needed.
Prostaglandin E1 (PGE) Injection
PGE1 (prostaglandin E1, also called alprostadil) is an intracavernosal injection used to treat erectile dysfunction (ED) in adult men. Each milliliter contains 40 micrograms of PGE1. The medication widens blood vessels in the penis, helping you achieve and keep an erection long enough for sexual activity. Use only as instructed by your healthcare provider.