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Active Ingredients
Important Disclaimer
These statements have not been evaluated by the Food and Drug Administration (FDA). Compounded products are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. The information provided is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting any new treatment.
Clinical Information
Evidence-based details for healthcare providers
Use as directed by your skincare provider. Apply a thin layer to clean, dry skin once or twice daily. If you miss a dose, apply it when you remember unless it is almost time for your next application. Do not apply extra cream to make up for a missed dose.
Kojic acid blocks an enzyme called tyrosinase that makes melanin, so less pigment forms and dark spots fade. Ascorbic acid is a powerful antioxidant that neutralizes damaging free radicals and supports collagen, helping skin look firmer and brighter. Hyaluronic acid pulls water into the outer skin layers, giving instant hydration and a plump feel. Hydration can be felt right away, but brightening and smoothing usually become noticeable after 4–8 weeks of steady use. Benefits last only while the cream is used; discoloration may return if treatment stops.
Do not use if you are allergic to kojic acid, hyaluronic acid, ascorbic acid, or any other ingredient in this cream. Do not apply to broken, irritated, or infected skin because it can worsen the area. Avoid use if you have active eczema or rosacea flare-ups on the treatment site unless approved by your provider. Not for children under 12 years old. If you are pregnant, planning pregnancy, or breastfeeding, speak with your healthcare provider before using because safety data are limited.
Using this cream with other strong exfoliating or bleaching products (such as retinoids, hydroquinone, alpha-hydroxy acids, beta-hydroxy acids, or benzoyl peroxide) may increase dryness or irritation—ask your provider before combining them. Topical steroids can thin skin and may raise sensitivity to this formula. Oral or topical medicines that make skin more sensitive to sunlight (for example, tetracycline antibiotics or sulfa drugs) can raise the risk of sunburn; use sunscreen. Tell your provider about all prescription, over-the-counter, herbal, and cosmetic products you use on your skin.
Very common (more than 1 in 10 users): mild stinging or tingling for the first few minutes after application; usually eases within 1–2 weeks. Common (1–10 in 100 users): redness, dryness, or peeling in the treated area; applying a fragrance-free moisturizer and reducing use to once daily often helps. Uncommon (1–10 in 1,000 users): temporary darkening of spots before they lighten, itching, or mild swelling. Rare but serious: severe rash, blistering, or facial swelling—stop use and seek medical help right away. Most mild side effects improve after the skin adjusts or after treatment stops.
Store at controlled room temperature (68–77 °F, 20–25 °C). Keep the cream in its original, tightly closed container and protect it from heat, high humidity, and direct sunlight. Do not freeze. Do not store in the bathroom. Tighten the cap after each use. Discard any unused cream 90 days after opening or by the labeled expiration date, whichever comes first. Return unused or expired medication to a pharmacy take-back program or mix it with coffee grounds in a sealed bag before throwing it in the trash.
Frequently Asked Questions
How long before I see results from this cream?
Most people notice brighter, more even skin in about 4–8 weeks. Full lightening of dark spots can take up to 12 weeks. Consistent daily use and sun protection speed results.
Should I use this cream in the morning or at night?
Follow your provider’s instructions. Many patients apply it at night to avoid sun exposure, but some use it twice daily. If used in the morning, always follow with a broad-spectrum SPF 30 or higher.
Can I combine this cream with my retinol or glycolic acid products?
These combinations can boost results but may also raise irritation. Use them only if your provider approves and start slowly—alternate nights or apply them at different times of day.
Is it safe to use during pregnancy or breastfeeding?
Safety data are limited. Talk with your obstetrician or dermatologist before using if you are pregnant, planning pregnancy, or breastfeeding.
What should I do if my skin becomes red or flaky?
Reduce application to once daily or every other day and apply a gentle, fragrance-free moisturizer. If irritation is severe or does not improve within a week, stop use and contact your healthcare provider.
Do I need to avoid the sun while using this cream?
Yes. The ingredients can make skin more sensitive to sunlight. Use broad-spectrum sunscreen, wear protective clothing, and limit tanning bed use to prevent burns and help the cream work better.
Related Products
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This prescription cream combines tretinoin 0.05%, hyaluronic acid 0.1%, and ascorbic acid (vitamin C) 2%. Together they help smooth fine lines, brighten dull skin, and improve moisture balance. It is designed for mild photo-aging, uneven tone, and dry or rough texture.
Hydroquinone | Retinoic Acid | Hyaluronic Acid | Ascorbic Acid (Vitamin C)
This prescription-strength cream combines four commonly used skin-brightening and anti-aging ingredients to target dark spots, uneven tone, and fine lines. Hydroquinone 8% helps lighten stubborn hyperpigmentation. Retinoic acid 0.05% speeds up skin cell turnover for smoother, fresher-looking skin. Hyaluronic acid 0.2% draws in moisture to plump and hydrate, while ascorbic acid (Vitamin C) 2% provides antioxidant protection and a healthy glow. The formula is intended for short-term, supervised use under a licensed healthcare provider.
Hydroquinone | Tretinoin | Kojic Acid | Azelaic Acid | Hydrocortisone
This compounded cream combines five commonly used dermatology ingredients to help reduce dark spots, calm inflammation, and even skin tone. Hydroquinone and kojic acid work together to lighten areas of excess pigment. Retinoic acid speeds up skin cell turnover, which can smooth texture and improve acne. Azelaic acid helps fight redness and bacteria, while a low dose of hydrocortisone eases irritation. Your healthcare provider may prescribe this formula for conditions such as melasma, post-inflammatory hyperpigmentation, or stubborn acne marks.
Triamcinolone | Hydroquinone | Tretinoin | Kojic acid Cream
Triamcinolone | Hydroquinone | Tretinoin | Kojic acid Cream is a compounded topical medication used under a prescriber’s direction to help improve the look of dark patches on the skin (hyperpigmentation), such as melasma. It combines an anti-inflammatory steroid (triamcinolone), pigment-reducing agents (hydroquinone and kojic acid), and a vitamin A–type medicine (tretinoin) that helps skin cells shed and renew. This product is made by a compounding pharmacy and is not an FDA-approved finished drug product.