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Available Strengths (3)·Most prescribed
Active Ingredients
Important Disclaimer
These statements have not been evaluated by the Food and Drug Administration (FDA). Compounded products are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. The information provided is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting any new treatment.
Clinical Information
Evidence-based details for healthcare providers
A valid prescription from a DEA-registered prescriber is required.
Limited to 5 refills within 6 months of the original prescription date.
Subject to state and federal controlled substance regulations.
Use as directed by your healthcare provider. If you miss a dose, take it when you remember unless it is almost time for your next dose. Do not double up on doses. Your provider will decide how long you should use this medicine.
Ketamine blocks N-methyl-D-aspartate (NMDA) receptors in the brain and spinal cord. This reduces the release of chemicals that send pain signals and can quickly change certain mood pathways. Most people feel effects within 5–15 minutes after a nasal dose, and the main effects last about 1–2 hours. Benefits for pain relief or mood support may last longer, but this varies by person.
Do not use if you are pregnant, trying to become pregnant, or breastfeeding (may harm the baby). Do not use if you have uncontrolled high blood pressure, a recent stroke, aneurysm, severe heart disease, active psychosis, or severe liver disease. Do not use if you are allergic to ketamine or any ingredient in this spray. Not for children under 18 unless a specialist directs its use.
Using ketamine with alcohol, opioids (such as oxycodone or morphine), benzodiazepines (such as lorazepam), or other drugs that slow the brain can increase drowsiness and breathing problems. MAO inhibitors (used for depression, like phenelzine) may raise blood pressure dangerously when combined with ketamine. Certain blood pressure medicines, especially clonidine or beta-blockers, can change how ketamine affects heart rate. Tell your provider about all medicines, vitamins, and herbal products you take, including St. John’s wort and valerian.
Very common (more than 1 in 10 people): dizziness, feeling “spaced out,” bitter taste in mouth. Common (1–10 in 100): nausea, high blood pressure, blurry vision, nasal irritation, anxiety. Uncommon (1–10 in 1,000): vomiting, rapid heart rate, hallucinations, ringing in ears. Rare but serious: severe high blood pressure, trouble breathing, prolonged confusion. Most mild effects fade within 1–2 hours. Seek emergency help if you have chest pain, severe confusion, or trouble breathing.
Store upright at room temperature (68-77°F, 20-25°C) in the original amber spray bottle. Protect from light, heat, and moisture. Do not freeze. Keep the cap tightly closed when not in use. Discard any leftover solution 60 days after first opening or on the beyond-use date on the label, whichever comes first. Take unused or expired medicine to a pharmacy take-back site or mix with coffee grounds in a sealed bag before throwing it away.
Frequently Asked Questions
How do I use the nasal spray correctly?
Blow your nose first, then shake the bottle gently. Tilt your head slightly forward and insert the tip into one nostril while closing the other. Press the pump one time and breathe in gently through your nose. Repeat in the other nostril if instructed by your provider.
When should I expect to feel relief?
Most people notice some effect within 5–15 minutes. Pain relief or mood changes may last several hours to a few days. Your provider will review your response and adjust the plan as needed.
Can I drive after using ketamine nasal spray?
No. Ketamine can slow reflexes, blur vision, and affect judgment for several hours. Do not drive, operate machinery, or make important decisions until the next day or until your provider says it is safe.
What if I feel dizzy or ‘out of body’ after a dose?
Sit or lie down right away to avoid falling. These feelings usually fade within an hour. If the sensation is severe or lasts longer than two hours, call your healthcare provider.
Is it okay to drink alcohol while using this medicine?
No. Alcohol increases the risk of dizziness, drowsiness, and breathing problems. Avoid all alcoholic drinks on the days you use the spray and for at least 24 hours afterward.
How do I store the bottle when traveling?
Keep the bottle in its protective case, upright, and at room temperature. Avoid leaving it in a hot car or direct sunlight. Carry it in your hand luggage, not checked baggage, and keep the cap on tight to prevent leaks.
What happens if the spray nozzle gets clogged?
Do not poke the nozzle with a pin. Instead, remove the cap and rinse the tip with warm water, then air dry and recap. If it stays clogged, contact your pharmacy for a replacement bottle.
Can pregnant or breastfeeding women use this medication?
No. Ketamine may harm an unborn baby and passes into breast milk. Tell your provider right away if you are pregnant, might become pregnant, or are breastfeeding.
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