Prescription RequiredCompoundedCIIIKetamine Nasal Spray
Ketamine Nasal Spray is a compounded prescription medicine prepared by a licensed pharmacy. It delivers ketamine through the nasal passages under the direction of your healthcare provider. Ketamine is an NMDA-receptor blocker first approved for anesthesia. When prescribed, it may help manage certain pain or mood conditions. This compounded product has not been reviewed by the FDA for safety or effectiveness, but it is made under USP <795> standards and state Board of Pharmacy rules.
Requires a valid prescription from your provider. Not sure if it's right for you? Ask a pharmacist.
These statements have not been evaluated by the Food and Drug Administration. Compounded products are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. This information is for educational purposes only and is not medical advice — always consult your healthcare provider before starting any new treatment.
Clinical information
Medication information for patients and providers.
A valid prescription from a DEA-registered prescriber is required.
Limited to 5 refills within 6 months of the original prescription date.
Subject to state and federal controlled-substance regulations.
Use as directed by your healthcare provider. If you miss a dose, take it when you remember unless it is almost time for your next dose. Do not double up on doses. Your provider will decide how long you should use this medicine.
Ketamine blocks N-methyl-D-aspartate (NMDA) receptors in the brain and spinal cord. This reduces the release of chemicals that send pain signals and can quickly change certain mood pathways. Most people feel effects within 5–15 minutes after a nasal dose, and the main effects last about 1–2 hours. Benefits for pain relief or mood support may last longer, but this varies by person.
Do not use if you are pregnant, trying to become pregnant, or breastfeeding (may harm the baby). Do not use if you have uncontrolled high blood pressure, a recent stroke, aneurysm, severe heart disease, active psychosis, or severe liver disease. Do not use if you are allergic to ketamine or any ingredient in this spray. Not for children under 18 unless a specialist directs its use.
Using ketamine with alcohol, opioids (such as oxycodone or morphine), benzodiazepines (such as lorazepam), or other drugs that slow the brain can increase drowsiness and breathing problems. MAO inhibitors (used for depression, like phenelzine) may raise blood pressure dangerously when combined with ketamine. Certain blood pressure medicines, especially clonidine or beta-blockers, can change how ketamine affects heart rate. Tell your provider about all medicines, vitamins, and herbal products you take, including St. John’s wort and valerian.
Very common (more than 1 in 10 people): dizziness, feeling “spaced out,” bitter taste in mouth. Common (1–10 in 100): nausea, high blood pressure, blurry vision, nasal irritation, anxiety. Uncommon (1–10 in 1,000): vomiting, rapid heart rate, hallucinations, ringing in ears. Rare but serious: severe high blood pressure, trouble breathing, prolonged confusion. Most mild effects fade within 1–2 hours. Seek emergency help if you have chest pain, severe confusion, or trouble breathing.
Store upright at room temperature (68-77°F, 20-25°C) in the original amber spray bottle. Protect from light, heat, and moisture. Do not freeze. Keep the cap tightly closed when not in use. Discard any leftover solution 60 days after first opening or on the beyond-use date on the label, whichever comes first. Take unused or expired medicine to a pharmacy take-back site or mix with coffee grounds in a sealed bag before throwing it away.
Frequently asked questions.
Blow your nose first, then shake the bottle gently. Tilt your head slightly forward and insert the tip into one nostril while closing the other. Press the pump one time and breathe in gently through your nose. Repeat in the other nostril if instructed by your provider.
Most people notice some effect within 5–15 minutes. Pain relief or mood changes may last several hours to a few days. Your provider will review your response and adjust the plan as needed.
No. Ketamine can slow reflexes, blur vision, and affect judgment for several hours. Do not drive, operate machinery, or make important decisions until the next day or until your provider says it is safe.
Sit or lie down right away to avoid falling. These feelings usually fade within an hour. If the sensation is severe or lasts longer than two hours, call your healthcare provider.
No. Alcohol increases the risk of dizziness, drowsiness, and breathing problems. Avoid all alcoholic drinks on the days you use the spray and for at least 24 hours afterward.
Keep the bottle in its protective case, upright, and at room temperature. Avoid leaving it in a hot car or direct sunlight. Carry it in your hand luggage, not checked baggage, and keep the cap on tight to prevent leaks.
Do not poke the nozzle with a pin. Instead, remove the cap and rinse the tip with warm water, then air dry and recap. If it stays clogged, contact your pharmacy for a replacement bottle.
No. Ketamine may harm an unborn baby and passes into breast milk. Tell your provider right away if you are pregnant, might become pregnant, or are breastfeeding.
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Bring this to the bench.
Transfer an existing prescription, or have your prescriber send a new one.