Prescription RequiredCompoundedCIVDiazepam Vaginal Cream
Diazepam vaginal cream is a compounded medicine used inside the vagina to relax tight pelvic floor muscles and ease pain. It contains the same active ingredient found in oral diazepam but is applied locally so less medicine reaches the rest of your body. Your healthcare provider may prescribe it for pelvic muscle spasm, pelvic pain, or painful intercourse. Use only as directed and talk with your provider if you have questions.
Requires a valid prescription from your provider. Not sure if it's right for you? Ask a pharmacist.
These statements have not been evaluated by the Food and Drug Administration. Compounded products are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. This information is for educational purposes only and is not medical advice — always consult your healthcare provider before starting any new treatment.
Clinical information
Medication information for patients and providers.
A valid prescription from a DEA-registered prescriber is required.
Limited to 5 refills within 6 months of the original prescription date.
Subject to state and federal controlled-substance regulations.
Use as directed by your healthcare provider. Insert the prescribed amount into the vagina, usually at bedtime. If you miss a dose, use it as soon as you remember unless it is almost time for your next dose. Do not use two doses at the same time.
Diazepam is a benzodiazepine that boosts the action of a calming chemical in your nerves called GABA. When placed inside the vagina, it relaxes tight pelvic floor muscles and lowers nerve sensitivity in the area. Most people notice some relief within 30–60 minutes, and the effect can last 6–8 hours. Regular nightly use over several weeks may give the best pain control.
Do not use if you are pregnant, planning to become pregnant, or breastfeeding (diazepam can harm an unborn baby and passes into breast milk). Do not use if you are allergic to diazepam or other benzodiazepines. Avoid if you have severe breathing problems, myasthenia gravis, narrow-angle glaucoma, or severe liver disease. Not for use in children.
Using other medicines that slow the brain, such as opioid pain pills (e.g., oxycodone), sleep aids (e.g., zolpidem), antihistamines (e.g., diphenhydramine), or alcohol may increase dizziness and drowsiness. Certain antifungals (ketoconazole), antibiotics (erythromycin), and HIV medicines (ritonavir) can raise diazepam levels. Tell your provider about all prescription, over-the-counter, and herbal products you use, including CBD and St. John’s wort.
Very common (more than 1 in 10 people): mild vaginal leakage of cream. Common (1–10 in 100 people): drowsiness, dizziness, tiredness, mild burning or irritation at the application site. Uncommon (1–10 in 1,000 people): blurred vision, unsteady walk, mood changes. Rare but serious: allergic reaction with rash, swelling of lips or throat, severe breathing trouble. Most mild side effects improve as your body adjusts. Contact your provider if side effects are severe, last more than a few days, or you notice signs of allergy.
Store at room temperature (68-77°F, 20-25°C). Keep the cap tightly closed and protect from heat, moisture, and direct light. Do not freeze. Keep out of reach of children and pets. Use within 90 days of compounding. Dispose of unused or expired cream through a pharmacy take-back program or mix with coffee grounds in a sealed bag before throwing it in the trash.
Frequently asked questions.
Wash your hands, fill the applicator with the prescribed amount, lie on your back with knees bent, and gently insert the applicator tip into the vagina. Push the plunger to release the cream, remove the applicator, and wash it with warm soapy water.
Because the cream is used locally, less diazepam reaches your bloodstream, so most people feel little or no sleepiness. Still, some drowsiness can occur. If you feel groggy, avoid driving or using machinery until you know how the medicine affects you.
Many women feel some muscle relaxation within the first hour. Lasting pain relief often improves after nightly use for 2–4 weeks. Keep using it as prescribed and let your provider know if pain is not improving.
It is best to limit or avoid alcohol. Alcohol can add to the drowsy effects of diazepam and may worsen dizziness or unsafe falls.
Yes, you may use the cream during menstruation unless your provider tells you otherwise. You might prefer using a panty liner to protect clothing from any extra leakage.
Stop using the cream and contact your healthcare provider right away. Diazepam can harm an unborn baby, and your provider will discuss safer options.
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