Semaglutide Sublingual

Semaglutide copies the action of a natural gut hormone called GLP-1. It binds to GLP-1 receptors, which triggers your pancreas to release more insulin when blood sugar is high and tells your liver to make less sugar. It also slows stomach emptying and sends fullness signals to your brain, helping you eat less. Most people feel reduced appetite within the first week, but blood-sugar control and weight changes usually appear after 4–8 weeks of regular use. Each dose works for about 24 hours.

Do not use if you or a family member has ever had medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2 (MEN 2) because it may raise the risk of thyroid tumors. Do not use if you are pregnant, planning to become pregnant, or breastfeeding, as safety is not established. Do not use if you are allergic to semaglutide or any ingredients in this suspension (may cause severe rash or swelling). Avoid if you have severe stomach or bowel disease like gastroparesis since the drug slows stomach emptying. Not approved for children under 18 years old.

Using semaglutide with insulin or sulfonylurea drugs (like glipizide, glyburide) may cause low blood sugar—check levels often and ask your provider about dose changes. It can slow absorption of oral medicines such as thyroid pills or antibiotics; take those at least 1 hour before semaglutide if possible. Combining with other GLP-1 agonists (exenatide, liraglutide) increases side effects and is not recommended. Warfarin levels may change—watch INR closely. Alcohol can increase risk of low blood sugar and stomach upset, so limit drinking. Tell your provider about all prescription drugs, over-the-counter medicines, vitamins, and herbal products you take.

Very common (more than 1 in 10 people): nausea, decreased appetite. Common (1–10 in 100 people): vomiting, diarrhea, constipation, stomach pain, headache, fatigue. Uncommon (1–10 in 1,000 people): gallstones, increased heart rate, injection-site reaction if combined with injectable GLP-1 drugs, mild dizziness. Rare but serious: pancreatitis (severe stomach pain that spreads to the back), kidney injury from dehydration, severe allergic reaction (rash, swelling of face or throat), thyroid tumors (lump or swelling in neck, hoarseness, trouble swallowing). Most stomach side effects improve after the first few weeks. Stop the drug and seek medical help right away if you get severe abdominal pain, yellow skin, or signs of an allergic reaction.

Store in the refrigerator at 36-46°F (2-8°C) in the original amber bottle to protect from light. Do not freeze. Keep the bottle tightly closed when not in use and avoid shaking. If refrigeration is not available, the suspension may be kept at room temperature (up to 77°F, 25°C) for a single period of up to 30 days, then discard any leftover. Keep away from children and pets. Dispose of unused or expired medicine through a pharmacy take-back program or mix with used coffee grounds in a sealed bag before throwing in household trash.