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Active Ingredients
Important Disclaimer
These statements have not been evaluated by the Food and Drug Administration (FDA). Compounded products are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. The information provided is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting any new treatment.
Clinical Information
Evidence-based details for healthcare providers
Use exactly as your prescriber directs. Apply a thin layer to the instructed area of intact skin, then wash your hands unless they are the treated area. Keep it away from eyes, mouth, and broken skin. Do not use a heating pad or a tight covering over the cream. Prevent children and pets from touching or licking treated skin. Protect treated skin from sunlight with clothing during treatment and for two weeks afterward. Avoid tanning beds and sunlamps.
Piroxicam and ketoprofen block enzymes involved in making prostaglandins, chemicals that contribute to inflammation and pain. Lidocaine blocks local nerve signals. The combination is intended for application at the painful area, but the amount absorbed through skin can vary.
Do not use if you are allergic to any ingredient or have had wheezing, hives, or another reaction to aspirin or similar anti-inflammatory medicines. Do not use around heart bypass surgery. Avoid use from 20 weeks of pregnancy unless specifically directed by your obstetric clinician; do not use from 30 weeks onward. Skin application does not eliminate fetal risk. Review kidney disease, ulcers, bleeding, and heart disease before use. Do not apply to damaged skin.
Ibuprofen, naproxen, aspirin, and other anti-inflammatory medicines can add to the risks of this two-drug anti-inflammatory combination. Blood thinners, steroids, some antidepressants, and certain blood pressure medicines need review. Include other lidocaine or numbing products in your medicine list.
Burning, redness, numbness, or a sun-related skin reaction may occur. Stop use and seek advice if a rash develops. Absorbed medicine can cause kidney problems, stomach bleeding, or heart-related problems. Seek urgent care for black stools, chest pain, breathing trouble, fainting, seizures, or a fast or irregular heartbeat.
Follow the storage directions and beyond-use date on your prescription label. Keep the medicine in its labeled container, out of reach of children and pets. Ask the pharmacist about disposal.
[FDA: Review of compounded topical pain creams](https://www.fda.gov/drugs/human-drug-compounding/nasem-assessment-safety-and-effectiveness-ingredients-used-compounded-topical-pain-creams)
[DailyMed: Piroxicam capsules label](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6039e036-c0aa-4249-af50-115f49ad758a)
[EMA: Topical ketoprofen photoallergy precautions](https://www.ema.europa.eu/en/medicines/human/referrals/ketoprofen-topical)
[DailyMed: Lidoderm lidocaine patch label](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=db0092f5-02a0-4076-ac32-969f075a6ab1)
Frequently Asked Questions
What is piroxicam, ketoprofen, and lidocaine cream used for?
A prescriber may consider it for localized pain after evaluating the cause. Evidence for compounded pain creams is limited. The treatment area, other medicines, and your health history guide whether this combination is appropriate.
Can I use this cream with ibuprofen or naproxen?
Ask your prescriber before combining them. The cream already contains two anti-inflammatory medicines, and some can enter the bloodstream. Adding more may increase bleeding, kidney, or heart-related risks without a clear reason.
Can I put a heating pad over this pain cream?
Do not place a heating pad or tight covering over the treated area. Heat and covering can change absorption. Keep the cream on intact skin and follow the directions for your specific prescription.
Is this FDA-approved?
No. This compounded medicine is prepared for one patient on a prescription. It is not FDA-approved. FDA does not review it for safety or effectiveness before it is made. Separately, FDA-approved piroxicam and ketoprofen capsules treat arthritis symptoms. FDA-approved lidocaine patches treat pain after shingles. Those approvals do not cover this three-ingredient cream.
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