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Important Disclaimer
These statements have not been evaluated by the Food and Drug Administration (FDA). Compounded products are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. The information provided is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting any new treatment.
Clinical Information
Evidence-based details for healthcare providers
Use as directed by your healthcare provider. Apply a thin layer to clean, dry skin. If you miss an application, apply it when you remember unless it is almost time for your next scheduled use. Do not apply extra cream to make up for a missed dose. Your provider will decide how long you should continue treatment.
NAD+ is a natural coenzyme that fuels cellular energy. When applied to the skin, it helps cells make more ATP, the body’s energy currency. Higher energy levels allow skin cells to build collagen, repair damage, and hold moisture better. Most users begin to notice smoother, firmer skin within 4–8 weeks of regular use, with benefits lasting as long as the cream is used consistently.
Do not use if you are allergic to Nicotinamide Adenine Dinucleotide or any ingredient in this cream (may cause rash or swelling). Do not apply to open wounds, infected skin, or severe burns (may worsen irritation). Not for use in children under 12 unless directed by a healthcare provider. If you are pregnant, planning to become pregnant, or breastfeeding, consult your provider before use due to limited safety data.
Using other strong facial treatments such as retinoids, alpha-hydroxy acids, or benzoyl peroxide at the same time may increase redness and peeling—space applications or ask your provider. Applying steroid creams on the same area may change how each product works; use under medical guidance. No known systemic drug interactions, but always tell your healthcare provider about all medicines, vitamins, and herbal products you use.
Very common (affects more than 1 in 10 people): mild redness or warmth at the application site, usually lasting less than 30 minutes. Common (affects 1–10 in 100 people): dryness, slight peeling, itching. Uncommon (affects 1–10 in 1,000 people): mild burning sensation, temporary rash. Rare but serious: severe allergic reaction with swelling or blistering—stop use and seek medical help right away. Most mild side effects improve as your skin adjusts within 1–2 weeks.
Store at room temperature (68–77°F, 20–25°C) in the original, tightly closed tube. Keep away from excessive heat, humidity, and direct sunlight. Do not freeze. Do not store in the bathroom. Use within 6 months of opening or by the expiration date, whichever comes first. Dispose of leftover or expired cream at a pharmacy take-back program or seal it in a bag with coffee grounds before placing in the trash.
Frequently Asked Questions
How often should I apply NADvantage cream?
Most people apply it once or twice a day, but follow the schedule your healthcare provider gives you. Using more often will not speed results and may cause extra irritation.
When will I start seeing results?
Skin usually looks smoother and feels softer after 4–8 weeks of steady use. Full benefits such as improved firmness and reduced fine lines may take 3 months or longer.
Can I use this cream with my current acne or anti-aging products?
Yes, but strong products like retinoids or alpha-hydroxy acids may increase irritation if layered together. Apply them at different times of day or on alternate days, and ask your provider for a personalized plan.
What if my skin gets red or itchy after using the cream?
Mild redness or itching is common and often fades as your skin adjusts. If discomfort is severe, lasts more than a few days, or includes swelling or blisters, stop using the cream and call your healthcare provider.
Is NADvantage safe during pregnancy or breastfeeding?
Safety data in pregnant or breastfeeding people are limited. Speak with your healthcare provider before starting or continuing use during these times.
Do I need to wear sunscreen while using this product?
Yes. Any rejuvenating skin product can make skin more sensitive to sunlight. Use a broad-spectrum SPF 30 or higher every day and avoid tanning beds.
How should I store the tube at home?
Keep it at room temperature, out of the bathroom, and away from direct sunlight or heat. Make sure the cap is tightly closed to prevent drying out.
Can I share my tube with someone else?
No. Sharing topical medications can spread bacteria and may not be safe for others with different skin conditions or allergies.
Related Products
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NAD+ (nicotinamide adenine dinucleotide) is a compounded injectable supplement prepared by prescription. It is supplied as a sterile solution for subcutaneous or intramuscular use. NAD+ is a coenzyme found in every cell and is involved in making energy. Your healthcare provider may prescribe it to support overall wellness, energy levels, and recovery. This product has not been reviewed or approved by the FDA for any specific disease and is provided only when a licensed prescriber determines it is appropriate.
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