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Active Ingredients
Important Disclaimer
These statements have not been evaluated by the Food and Drug Administration (FDA). Compounded products are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. The information provided is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting any new treatment.
Clinical Information
Evidence-based details for healthcare providers
Use as directed by your healthcare provider. Apply a thin, even layer to clean, dry skin and cover if instructed. Do not exceed the recommended amount or leave on longer than advised. If you miss a scheduled application before a procedure, tell your provider. Do not apply more gel to make up for a missed dose.
The gel contains three local anesthetics that block tiny channels (sodium channels) in nerve endings under the skin. When these channels are blocked, pain signals cannot travel to the brain, so the area feels numb. Numbing usually begins 15–30 minutes after application and can last 30–60 minutes after the gel is removed. Patients will notice less or no pain during the planned skin procedure.
Do not use if you are allergic to lidocaine, tetracaine, prilocaine, other local anesthetics, or any ingredient in this gel (may cause severe rash or swelling). Do not use on broken or infected skin, inside the mouth, or near the eyes. Do not use if you have a history of methemoglobinemia or certain blood disorders such as G6PD deficiency (can worsen oxygen problems). Avoid if you have severe liver disease, heart rhythm problems, or are younger than 2 years old. If you are pregnant or breastfeeding, consult your healthcare provider before use.
Using other medicines that raise methemoglobin levels (such as nitrates, nitrites, dapsone, sulfonamides, or certain anti-malaria drugs) can increase the risk of low blood oxygen. Class I anti-arrhythmic drugs (e.g., mexiletine) may raise blood levels of lidocaine, leading to side effects. Beta-blockers, cimetidine, and certain antidepressants can slow the breakdown of lidocaine in the liver, raising risk of toxicity. Tell your provider about all prescription, over-the-counter, and herbal products you take. Limit alcohol, which can stress the liver.
Very common (more than 1 in 10 people): mild redness or whitening of the skin where the gel is applied, temporary burning or tingling that fades within minutes. Common (1–10 in 100 people): swelling, itching, or small pinpoint bruises. Uncommon (1–10 in 1000 people): dizziness, headache, nausea. Rare but serious: rapid heartbeat, shortness of breath, gray-blue skin tone (signs of methemoglobinemia), seizure, severe allergic reaction with swelling of face or throat. Most mild effects go away shortly after the gel is removed. Seek medical help right away for serious symptoms.
Store at room temperature (68-77°F, 20-25°C) in the original, tightly closed jar. Keep away from heat, direct sunlight, and moisture. Do not freeze. Keep out of reach of children and pets. Do not use after the expiration date. Dispose of unused or expired gel through a pharmacy take-back program or mix with coffee grounds in a sealed bag before placing in the household trash.
Frequently Asked Questions
How long before my procedure should I apply the gel?
Follow the timing your healthcare provider gives you. In general, the gel is applied 30–60 minutes before the procedure so the skin has time to numb.
Can I use this gel on open cuts or inside my mouth?
No. The gel is only for intact skin. Using it on open wounds or mucous membranes can cause serious side effects and faster drug absorption.
What should I do if the skin turns red or burns after I apply it?
Mild redness or a brief stinging feeling is common and usually fades quickly. If the area becomes very painful, swollen, or develops a rash, wash the gel off with mild soap and water and call your provider.
Is it safe to drive after using this anesthetic gel?
Most people can drive because the gel acts only where it is applied. However, if you feel dizzy, lightheaded, or unwell, wait until you feel normal before driving.
Can I apply more gel if I still feel sensation?
Do not apply extra gel unless your provider tells you to. Too much can lead to serious side effects, including heart or breathing problems.
How should I store the jar once it is opened?
Keep the lid tightly closed and store the jar at room temperature away from heat and sunlight. Make sure children and pets cannot reach it.
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