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Active Ingredients
Important Disclaimer
These statements have not been evaluated by the Food and Drug Administration (FDA). Compounded products are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. The information provided is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting any new treatment.
Clinical Information
Evidence-based details for healthcare providers
Use as directed by your healthcare provider. Swallow the capsule with water at the same time each day unless told otherwise. If you miss a dose, take it when you remember unless it is almost time for your next dose. Do not take two doses at once.
DHEA and pregnenolone are naturally made in your adrenal glands. In the body they convert into other hormones such as estrogen, testosterone, and cortisol. By providing extra amounts, the capsules can raise low hormone levels, which may improve energy, mood, memory, and well-being. The modified-release coating lets the hormones absorb slowly over 6–8 hours, helping maintain steadier blood levels during the day. Most patients feel benefits within 2–4 weeks, but full effects may take 2–3 months of regular use.
Do not use if you are pregnant, trying to become pregnant, or breastfeeding (may affect fetal and infant development). Do not use if you have hormone-sensitive cancers such as breast, uterine, ovarian, or prostate cancer. Do not use if you have severe liver disease, untreated thyroid disorders, or adrenal tumors. Do not use if you are allergic to DHEA, pregnenolone, or any capsule ingredients. Not for use in children under 18 without specialist supervision.
May increase effects of hormone therapies (estrogen, testosterone), raising side-effect risk. Can reduce effectiveness of corticosteroid medicines like prednisone. May interact with blood thinners such as warfarin, increasing bleeding risk—your doctor may order extra INR checks. Stimulant medications (for ADHD) and caffeine may worsen insomnia or anxiety when combined. High-dose vitamin E or fish oil may add to bleeding risk. Always show your full medication and supplement list to your prescriber before starting.
Very common (affects more than 1 in 10 people): mild acne, oily skin. Common (1–10 in 100 people): facial hair growth in women, mood changes (irritability, anxiety), trouble sleeping, headache, stomach upset. Uncommon (1–10 in 1,000 people): breast tenderness, hair thinning, rapid heartbeat, high blood pressure. Rare but serious: liver enzyme changes, severe mood swings, allergic reaction (rash, swelling, trouble breathing). Most mild effects improve after dose adjustment or stopping the medicine. Seek medical help right away for serious or persistent symptoms.
Store at room temperature 68-77 °F (20-25 °C). Keep the capsules in their original, tightly closed container away from moisture, heat, and direct light. Do not store in the bathroom or kitchen. Keep out of reach of children and pets. Stable for 24 months from the date on the label. Dispose of unused or expired capsules through a pharmacy take-back program or mix with coffee grounds in a sealed bag before placing in household trash.
Frequently Asked Questions
When is the best time to take my DHEA and pregnenolone capsule?
Take it at the same time each day, usually in the morning with food, unless your provider tells you differently. Morning dosing matches your body’s natural hormone rhythm and helps avoid sleep problems.
How long before I feel better?
Many people notice more energy or better mood within a few weeks. Hormone levels usually balance after 2–3 months, so full benefits may take that long.
Can I drink alcohol while on this medication?
Light to moderate alcohol is usually safe, but heavy drinking can stress your liver and reduce the medicine’s benefits. Limit alcohol and talk with your provider if you drink regularly.
What lab tests will I need?
Your provider may order blood tests for DHEA-S, pregnenolone, estrogen, testosterone, and liver function every 3–6 months. These tests make sure your levels stay in a healthy range.
Are these capsules safe for women?
They can be safe when carefully monitored, but women who are pregnant, breastfeeding, or have hormone-sensitive cancers must not use them. Always use birth control and have regular check-ups if you are of child-bearing age.
What if I notice acne or hair growth?
These are common side effects from higher androgen levels. Tell your provider—your dose may need to be lowered or the timing adjusted. Most skin changes improve after the dose is changed.
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