Clinical Information
Use as directed by your healthcare provider. Apply a thin layer to clean, dry skin on the affected area once or twice daily, or as instructed. Wash hands after use unless treating them. If you miss an application, use it when you remember unless it is almost time for the next one. Do not apply extra cream to make up for a missed dose.
GHK-Cu is a small peptide bound to copper. It signals skin cells to make more collagen and elastin, proteins that keep skin firm and elastic. It also helps remove damaged proteins and supports new blood vessel growth, improving skin tone. Most users notice softer, smoother skin in 4–8 weeks, with firmer texture and reduced fine lines after 3–4 months of steady use. Effects last as long as the cream is used regularly.
Do not use if you are allergic to copper, peptides, or any ingredients in this cream (may cause rash or swelling). Do not apply to broken, infected, or sunburned skin. Do not use if you are pregnant or breastfeeding unless your provider decides the benefit outweighs the risk. Not for use in children under 18 without medical supervision.
Avoid using at the same time as strong acids or exfoliants (like glycolic acid >10% or salicylic acid peels); these can inactivate the peptide. Retinoids (such as tretinoin) may increase skin irritation; use at opposite times of day if both are prescribed. Products containing zinc or iron in high amounts may compete with copper uptake and lower effectiveness. Tell your provider about all topical and oral medicines, vitamins, and herbals you use.
Common (up to 1 in 10 users): mild redness, tingling, or dryness at the application site; usually improves within a week. Uncommon (1–5 in 1000 users): peeling, itching, or small bumps; stop use and call your provider if bothersome. Rare but serious: allergic contact dermatitis with swelling, severe itching, or blistering—wash off immediately and seek medical help.
Store at room temperature (68–77°F, 20–25°C) in the original, tightly closed container. Keep away from heat, high humidity, and direct sunlight. Do not freeze. Do not store in a bathroom. Keep out of reach of children and pets. Discard any unused cream 90 days after first opening or by the labeled expiration date, whichever comes first. Use a pharmacy take-back program or mix leftover cream with coffee grounds in a sealed bag before throwing it away.
Frequently Asked Questions
Q:How long before I see results from GHK-Cu cream?
A:Most people notice skin feeling softer within a few weeks. Firmer texture and visible changes in fine lines usually appear after 3–4 months of daily use. Consistency is key.
Q:Can I use this cream with my retinol product?
A:Yes, but apply them at different times to lower the chance of irritation. Many people use GHK-Cu in the morning and retinol at night. Ask your provider for a schedule that fits your routine.
Q:What should I do if my skin gets red or itchy?
A:Mild redness or tingling often fades as your skin adjusts. If itching or burning lasts more than a few days, stop using the cream and contact your healthcare provider. Severe reactions need medical attention right away.
Q:Is it safe during pregnancy or breastfeeding?
A:The safety of GHK-Cu in pregnancy and breastfeeding has not been well studied. Do not use unless your provider decides the benefits are greater than the risks. Always discuss this with your prenatal care team.
Q:Can I wear makeup after applying the cream?
A:Yes. Let the cream absorb for about 5–10 minutes, then apply sunscreen and makeup as usual. Using sunscreen daily helps protect the new collagen your skin is making.
Q:Does the cream have a copper smell or color?
A:The formula may have a very light blue tint from the copper peptide but should not stain skin or clothes. It is fragrance-free and should not have a strong odor.
Q:How should I store the cream while traveling?
A:Keep it in its sealed container, away from direct sun or hot cars. A room-temperature toiletry bag is fine. Do not refrigerate or freeze, as extreme temperatures can break down the peptide.
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