Clinical Information
Use as directed by your healthcare provider. Apply a thin layer to clean, dry skin once or twice daily, or as instructed. If you forget to apply, use it when you remember unless it is almost time for your next application. Do not apply extra cream to make up for a missed dose.
GHK-Cu is a small peptide that binds copper ions. On the skin, it signals cells called fibroblasts to make more collagen and elastin, the proteins that give skin strength and elasticity. It also attracts immune cells that help repair damage and reduces enzymes that break down collagen. Most users notice smoother texture and better firmness after 4–8 weeks, with continued improvement for several months if used regularly.
Do not use if you are allergic to copper peptides or any ingredients in this cream (may cause rash or itching). Do not apply to broken or infected skin, active rashes, or open wounds (may delay healing). Avoid use if you have a known copper metabolism disorder such as Wilson’s disease. Consult your provider before use if you are pregnant, planning pregnancy, or breastfeeding, as safety has not been established for unborn or nursing babies. Not for use on children under 12 years of age unless specifically directed by a pediatric dermatologist.
Topical GHK-Cu is not known to interact with most oral or topical medicines, but using multiple active skin products together may increase irritation. Avoid layering this cream directly with strong acids (like glycolic acid), retinoids (such as tretinoin), or benzoyl peroxide unless your provider advises—these combinations may reduce effectiveness or raise the chance of redness and peeling. Do not mix with other copper-containing products to prevent excess copper absorption. Tell your provider about all prescription creams, over-the-counter lotions, herbal products, and supplements you use on your skin.
Very common (affects more than 1 in 10 users): mild stinging or tingling for a few minutes after application; usually fades quickly. Common (1–10 users in 100): temporary redness, dry patches, or flaking during the first two weeks; often improves as skin adjusts. Uncommon (1–10 users in 1,000): itching, darkening of healed scars, or mild breakout in acne-prone skin. Rare but serious: allergic contact dermatitis with severe rash or swelling—stop use and seek medical help right away. Most side effects go away within days after stopping the cream.
Store tightly closed at room temperature 68-77°F (20-25°C). Protect from direct sunlight, heat, and excess humidity; do not store in the bathroom. Keep in the original jar or pump to prevent contamination. Do not freeze. Discard any unused cream 90 days after first opening or by the printed expiration date, whichever comes first. Dispose of leftover product through a pharmacy take-back program or seal in a bag with household trash—do not flush.
Frequently Asked Questions
Q:How long before I see results with GHK-Cu cream?
A:Most people notice softer, smoother skin in about 4 weeks. Firmer skin and reduced fine lines usually appear after 8–12 weeks of daily use. Keep using the cream as directed to maintain benefits.
Q:Where should I apply the cream?
A:Apply a thin layer to clean, dry skin on the face, neck, or other areas your provider recommends. Avoid eyelids, lips, and any broken or irritated skin unless your healthcare provider says it is safe.
Q:Can I use this cream with my retinol or acid exfoliants?
A:Using retinol or strong exfoliating acids at the same time can increase redness or dryness. If your provider approves both, apply them at different times of day (for example, GHK-Cu in the morning and retinol at night) or on alternating days.
Q:Is it safe to use while pregnant or breastfeeding?
A:Safety data in pregnancy and breastfeeding are limited. Talk with your obstetrician or dermatologist before starting this cream if you are pregnant, planning to become pregnant, or nursing.
Q:What if my skin gets irritated?
A:Mild tingling or redness is common at first and often improves. If irritation lasts more than a few days, skip a day or reduce to once-daily use. Stop the cream and contact your provider right away if you develop a rash, swelling, or severe burning.
Q:How should I store and travel with the cream?
A:Keep it at normal room temperature and out of direct sun. For travel, place the closed jar or pump in a sealed plastic bag and keep it below 86°F (30°C). Do not leave it in a hot car or checked luggage where temperatures can rise.
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