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Active Ingredients
Important Disclaimer
These statements have not been evaluated by the Food and Drug Administration (FDA). Compounded products are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. The information provided is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting any new treatment.
Clinical Information
Evidence-based details for healthcare providers
Use exactly as directed by your healthcare provider. Inject the medicine under the skin once each week on the same day. If you forget a dose and it is within 5 days of your usual day, take it as soon as you remember. If more than 5 days have passed, skip the missed dose and take your next dose on the regular day. Never take two doses at the same time.
Semaglutide attaches to GLP-1 receptors in your pancreas, brain, and stomach. This boosts insulin release when blood sugar is high, lowers the hormone glucagon, slows how fast food leaves the stomach, and reduces appetite signals in the brain. Blood sugar may improve within the first week, while noticeable weight loss often begins after 4-8 weeks and continues with ongoing use. Each dose works for about seven days because the medicine stays in the body a long time.
Do not use if you have or a family member has medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) because the medicine may raise thyroid tumor risk. Do not use if you are pregnant, planning pregnancy, or breastfeeding. Do not use if you are allergic to semaglutide or any of its ingredients. Not for use in children under 18 years old. Do not use during episodes of diabetic ketoacidosis.
Using semaglutide with insulin or medicines that raise insulin, such as sulfonylureas (glipizide, glimepiride), can cause low blood sugar. Tell your provider about all diabetes medicines so doses can be adjusted. Semaglutide may slow the emptying of your stomach, which can change how quickly oral medicines like birth control pills, antibiotics, or thyroid pills are absorbed; take them at least one hour before the shot if possible. Avoid taking other GLP-1 medicines (liraglutide, dulaglutide) at the same time. Heavy alcohol use can increase stomach side effects and risk of low blood sugar. Check with your provider before starting new vitamins, herbs, or over-the-counter drugs.
Very common (more than 1 in 10 people): nausea (up to 44%), diarrhea, vomiting, constipation. These stomach issues often improve within a few weeks as your body adjusts. Common (1-10 in 100 people): stomach pain, burping, tiredness, headache, injection-site redness or itch, mild low blood sugar when used with other diabetes drugs. Uncommon (1-10 in 1000 people): gallstones, pancreatitis (severe belly pain that will not go away), worsening retinopathy in people with long-standing diabetes, allergic reactions like rash or swelling. Rare but serious: kidney problems from dehydration, thyroid tumors (lump in neck, hoarseness, trouble swallowing). Call your provider right away if you have severe stomach pain, yellow skin or eyes, a lump in your neck, or signs of an allergic reaction. Most mild side effects lessen over time or after dose adjustment.
Store unopened vials in the refrigerator at 36-46°F (2-8°C). Do not freeze; throw away if the medicine has been frozen. Once first used, the vial may be kept in the refrigerator or at room temperature below 86°F (30°C) for up to 28 days. Keep the vial in the original box to protect it from light and moisture, and keep the rubber stopper clean. Do not shake. Discard any leftover medicine 28 days after first puncture or after the expiration date, whichever comes first. Dispose of used needles in a sharps container and bring expired or unused medicine to a pharmacy take-back program or follow local disposal rules.
Frequently Asked Questions
How do I give myself the semaglutide shot?
Wash your hands, wipe the vial’s rubber top with alcohol, draw the dose into the syringe, and inject under the skin of your stomach, thigh, or upper arm. Use a new needle each time and rotate sites to avoid lumps or irritation.
When will I start losing weight?
Many people notice less appetite within the first week. Visible weight loss usually starts after 4-8 weeks of steady weekly injections combined with healthy eating and exercise. Full benefits build over several months.
What should I do if I feel very nauseous?
Eat smaller meals, avoid greasy or spicy foods, and drink clear liquids. If nausea is severe or won’t go away, call your provider; they may lower your dose or give you tips to manage the upset stomach.
Is semaglutide safe for people with thyroid problems?
Do not use semaglutide if you or a close family member has medullary thyroid cancer or MEN 2. If you have other thyroid issues like hypothyroidism, talk with your provider; most people with regular thyroid problems can use it safely.
How should I store the vial after opening?
Keep it in the fridge or at room temperature below 77°F. Always write the date you first puncture the vial on its label and throw it away 28 days later even if liquid remains.
What happens if I miss my weekly dose?
If your missed dose is within five days of the scheduled day, inject it as soon as you remember. If more than five days have passed, skip it and take your next dose on the regular day.
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