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Available Strengths (3)·Most prescribed
Active Ingredients
Important Disclaimer
These statements have not been evaluated by the Food and Drug Administration (FDA). Compounded products are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. The information provided is for educational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting any new treatment.
Clinical Information
Evidence-based details for healthcare providers
Wash and dry the affected skin. Apply a thin layer of cream to the dark spot(s) once daily at bedtime. Gently rub in until the cream disappears. Do not use more than twice in 24 hours. Use sunscreen (SPF 30 or higher) every morning while using this product. Treatment usually lasts 8–12 weeks; stop and see your doctor if you do not see improvement after 3 months. If you forget a dose, apply it as soon as you remember unless it is within 6 hours of your next scheduled dose—then skip the missed dose. Do not double up.
Hydroquinone blocks an enzyme called tyrosinase, which your skin needs to make melanin, the pigment that gives skin its color. By slowing melanin production, the cream lightens existing dark spots and helps prevent new pigment from forming. Most people start to notice fading in 4–6 weeks, with full results in about 8–12 weeks. The effect lasts as long as you protect your skin from the sun and avoid other causes of dark spots.
Do not use if you are allergic to hydroquinone or any cream ingredients (can cause severe rash). Do not use on broken, irritated, or sun-burned skin. Do not use if you are pregnant, planning pregnancy, or breastfeeding; safety is not known. Not for use in children under 12 years. Avoid if you have a history of ochronosis (bluish-black skin discoloration) or significant skin sensitivity.
Avoid using products that contain benzoyl peroxide, hydrogen peroxide, or resorcinol at the same time; they can darken the skin temporarily. Using retinoids (like tretinoin) or alpha-hydroxy acids may increase skin irritation—apply them at a different time of day if prescribed together. Tell your doctor about all prescription and over-the-counter skin products, vitamins, and herbal creams you use. Limit sun exposure and do not use tanning beds, as UV light can reduce the cream’s benefits and raise irritation risk.
Very common (more than 1 in 10 people): mild redness, dryness, or stinging at the application site—usually improves within 1–2 weeks. Common (1–10 in 100 people): mild itching, peeling, or increased sun sensitivity. Uncommon (1–10 in 1,000 people): allergic rash, swelling, blistering—stop use and call your doctor. Rare but serious: blue-black skin discoloration (ochronosis) with long-term or excessive use; seek medical advice immediately. Most side effects go away after you stop the cream.
Store tightly closed at room temperature, 59-86°F (15-30°C). Keep away from heat, moisture, and direct light; do not freeze. Use the original container to protect the medicine from air and light. Do not store in the bathroom. Keep out of reach of children and pets. Discard leftover or expired cream through a pharmacy take-back program or mix with used coffee grounds in a sealed bag before throwing in household trash.
Frequently Asked Questions
How long before I see results?
Most people notice the dark spots start to fade in 4–6 weeks. Full lightening can take 8–12 weeks if you use the cream every night and protect your skin from the sun.
Should I apply moisturizer or sunscreen with this cream?
Yes. Use a gentle moisturizer after the cream dries if your skin feels dry. Apply a broad-spectrum sunscreen (SPF 30 or higher) every morning to protect treated areas and prevent new spots.
Can I use this cream on my whole face?
No. Apply only to the dark spots or small surrounding area, not the entire face. Using it on normal skin can cause uneven lightening.
Is it safe to use during pregnancy or while breastfeeding?
No. Hydroquinone has not been proven safe for unborn or nursing babies. Stop use and talk with your healthcare provider if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if the cream irritates my skin?
Mild redness or stinging often gets better within a week. If irritation is strong or gets worse, skip a day between applications or stop use and call your doctor.
Can I keep using the cream after my spots fade?
Use the cream only as long as prescribed, usually no more than 12 weeks at a time. Once your spots fade, stop and continue using sunscreen to help maintain results.
Will the spots come back when I stop using the cream?
They can if your skin is exposed to sun, hormones, or other triggers. Protecting your skin with sunscreen and avoiding harsh products can help keep spots from returning.
What happens if I accidentally apply too much?
Wipe off the extra and wash your hands. Using more cream than directed will not speed results and may raise the risk of irritation or unwanted lightening.
Related Products
Hydroquinone | Tretinoin | Kojic Acid
This compounded skin-lightening cream combines three commonly used ingredients to help fade dark spots, melasma, and other areas of uneven skin color. Hydroquinone blocks the formation of skin pigment, Retinoic Acid speeds up skin cell turnover, and Kojic Acid further slows pigment production. Your prescriber will tell you how long to use it and when to check progress. The formula is prepared in a smooth, easy-to-apply cream base and is dispensed in a 30-gram container.
Hydroquinone | Kojic Acid | Tretinoin | Hydrocortisone Cream
This compounded cream is used to lighten dark spots on the skin such as melasma, sun spots, and post-inflammatory hyperpigmentation. It combines four active ingredients that work together to slow down pigment production, speed skin turnover, and calm irritation, helping the skin look more even over time.
Hydroquinone | Tretinoin | Kojic Acid | Azelaic Acid | Hydrocortisone
This compounded cream combines five commonly used dermatology ingredients to help reduce dark spots, calm inflammation, and even skin tone. Hydroquinone and kojic acid work together to lighten areas of excess pigment. Retinoic acid speeds up skin cell turnover, which can smooth texture and improve acne. Azelaic acid helps fight redness and bacteria, while a low dose of hydrocortisone eases irritation. Your healthcare provider may prescribe this formula for conditions such as melasma, post-inflammatory hyperpigmentation, or stubborn acne marks.
Hydroquinone | Tretinoin | Kojic Acid | Niacinamide | Hydrocortisone Cream
A compounded topical cream that may be prescribed to help improve the look of dark spots and uneven skin tone. It combines ingredients that reduce excess skin pigment, increase skin cell turnover, calm irritation, and support the skin barrier. This medication should be used only under the direction of a licensed healthcare provider because it contains high-strength hydroquinone and a topical steroid.