Clinical Information
Use as directed by your healthcare provider. Apply a thin layer to the affected nipple area after each feeding unless told otherwise. If you miss an application, use it when you remember unless it is almost time for the next feeding. Do not double up. Your healthcare provider will tell you how long to continue treatment.
Mupirocin stops certain skin bacteria from making the proteins they need to grow. Miconazole weakens the cell walls of yeast, causing the yeast to die. Betamethasone lowers swelling, redness, and itching by calming the body’s immune response in the skin. Most people feel less pain and see less redness within 2–3 days. Full relief usually happens in about one week if used regularly.
Do not use if you are allergic to mupirocin, miconazole, betamethasone, or any ointment base ingredients (can cause rash or swelling). Do not use on broken skin that is deep or seriously damaged. Avoid if you have untreated viral infections (such as cold sores) on the nipple. Talk to your healthcare provider before use if you or your baby have a weakened immune system or if your baby was born premature.
When used on small skin areas, drug interactions are unlikely. Still, tell your healthcare provider about all medicines, especially other topical antibiotics, antifungals, or steroids. Large amounts of miconazole on the skin can rarely raise warfarin (Coumadin) levels, increasing bleeding risk. Avoid applying other creams or lotions to the same area unless your provider says it is okay. Limit alcohol, which can worsen skin dryness.
Very common (more than 1 in 10): mild stinging or burning right after applying; usually lasts a few minutes. Common (1–10 in 100): itching, dryness, or redness around the nipple. Uncommon (1–10 in 1,000): skin thinning, stretch marks, or lightening of skin color after long-term use. Rare but serious: severe allergic reaction with rash, swelling of lips or face, or trouble breathing—stop use and seek emergency help. Most mild side effects fade within a few days and improve after stopping the ointment.
Store at room temperature (68-77°F, 20-25°C) in a dry place away from direct sunlight. Keep the cap tightly closed. Do not freeze. Keep out of reach of children and pets. Throw away any leftover ointment after the date printed on the label. Use a pharmacy take-back program or mix unused ointment with coffee grounds in a sealed bag before placing it in household trash.
Frequently Asked Questions
Q:How do I apply the ointment without getting it on my baby?
A:After each feeding, wash your hands, apply a thin layer to the sore nipple, and let it air-dry for a minute or two. There is no need to wipe it off before the next feeding unless your provider tells you otherwise.
Q:When will my pain and soreness get better?
A:Most mothers feel less pain within 2–3 days. If your symptoms have not improved in a week or get worse, contact your healthcare provider.
Q:Is it safe for my baby to ingest a small amount while nursing?
A:In the small amounts used on the nipple, the ingredients are considered low-risk for healthy full-term infants. Still, only use as prescribed and tell your pediatrician if your baby develops mouth redness, thrush, or upset stomach.
Q:Can I use other nipple creams or lotions at the same time?
A:Avoid layering other products on top of this ointment unless your healthcare provider says it is okay. Mixing creams can dilute the medicine and lower its effect.
Q:What if my nipples remain cracked and bleeding?
A:Stop nursing on the affected side if advised and call your healthcare provider or lactation consultant. You may need a different treatment or a change in your baby’s latch technique.
Q:How should I store the ointment when traveling?
A:Keep it in its original tube, sealed, and store it below 77°F (25°C). Do not leave it in hot cars or direct sunlight as heat can break down the medicine.
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